Academic Interests

Research has been focusing on the protein-protein interactions in signaling cascades, especially interactions between protein kinases and phosphatase and their involvement in inflammatory disease and cancer. Ongoing research is to study the signaling mechanisms in podocytes in response to a variety of stimuli, including activation of the complement system. Podocyte is an essential component of the glomerular filtration barrier and podocyte injury is closely associated with the development of many types of glomerulopathies. Understanding the underlying signaling mechanisms in podocyte injury will benefit the development of targeted therapy of glomerular disease.

Representative Publications

  1. Chen P et al. Identification of novel FLT3/ITD signaling targets by CEP-701 inhibition in a phosphoproteomic study.
  2. Chen P et al. FLT3/ITD Mutation Signaling Includes Suppression of SHP-1 J. Biol. Chem., , 2005, 280: 5361-5369.
  3. Chen P, et al. Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide- stimulated macrophages. J Immunol. 2002, 169: 6408-16.
  4. Chen P, et al. A mammalian expression system for rapid production and purification of active MAP kinase phosphatases. Protein Expr Purif. 2002, 24:481-8.
  5. Chen P, Hutter D, Yang X, Gorospe M, Davis RJ, Liu Y. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically. J Biol Chem. 2001, 276:29440-9.

More Information

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