Section of Emergency Medicine
Professor of Medicine
Harold Hines Jr. Professor of Medicine; Director, Center for Systems Biology & Oxygen Sensing
|PhD||1980||M.S. University, Baroda, India||Physiology
|D.Sc||1982||Ruhr University, Bochum, Germany||Biology
Dr. Prabhakar is a leading authority in the field of O2 sensing and physiological consequences of chronic hypoxia. Substantial population of adult humans and nearly 50% of premature infants experience chronic intermittent hypoxia as a consequence of sleep-disordered breathing manifested as recurrent apneas. People with recurrent apneas develop serious morbidities including hypertension, ventilatory abnormalities, myocardial infarctions, metabolic syndrome and even stroke. Using rodent and cell culture models of intermittent hypoxia, Dr. Prabhakar’s lab identified novel signaling pathways and molecular mechanisms underlying the morbidity associated with chronic intermittent hypoxia.
- Prabhakar NR, Semenza GL. Oxygen Sensing and Homeostasis. Physiology (Bethesda). 2015 Sep;30(5):340-8. doi: 10.1152/physiol.00022.2015. Review.
- Nanduri J, Prabhakar NR. Epigenetic Regulation of Carotid Body Oxygen Sensing:Clinical Implications. Adv Exp Med Biol. 2015;860:1-8.
- Prabhakar NR, Semenza GL. Regulation of carotid body oxygen sensing by hypoxia-inducible factors. Pflugers Arch. 2016 Jan;468(1):71-5.
- Semenza GL, Prabhakar NR. Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea. J Appl Physiol (1985). 2015 Nov 15;119(10):1152-6
- Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 2015 Apr 21;8(373):ra37.