Jeannette Messer
Section of Gastroenterology
Instructor of Medicine


DVM2001Michigan State UniversityVeterinary Medicine
MS2005Ohio State UniversityVeterinary Clinical Sciences (Comparative Physiology)
Residency2005Ohio State UniversitySmall Animal Internal Medicine
PhD2013The University of ChicagoImmunology

Academic Interests

Dr. Messer's research focuses on host-microbe interactions in the gastrointestinal tract and how disruptions to those interactions lead to disease throughout the body. Specifically, she is interested in how intestinal epithelial responses to microbes contribute to development of type 2 diabetes mellitus and non-alcoholic fatty liver disease. This research will define fundamental mechanisms of gut-liver crosstalk and the role of intestinal responses to microbes in the pathogenesis of metabolic disease. It will also pinpoint inflammatory triggers for metabolic disease initiation and progression in the intestine where they can be monitored through minimally invasive methods and targeted therapeutically to limit and reverse disease in the liver, pancreas, and other target organs of metabolic disease.

Representative Publications

  1. Messer JS*, Murphy SF*, Logsdon MF, Lodolce JP, Grimm WA, Bartulis SJ, Vogel TP, Burn M, Boone DL. The Crohn's disease: associated ATG16L1 variant and Salmonella invasion. BMJ Open. 2013 Jun 20;3(6). doi:pii: e002790. 10.1136/bmjopen-2013-002790. Print 2013. *Co-first authors
  2. Zhai Z, Wu F, Dong F, Chuang AY, Messer JS, Boone DL, Kwon JH. Human autophagy gene ATG16L1 is post-transcriptionally regulated by MIR142-3p. Autophagy. 2014 Jan 6;10(3). [Epub ahead of print] PMID: 24401604
  3. Messer JS*, Tao, Y*, Goss KH, Hart J, Bissonnette M, Chang EB. Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model. Carcinogenesis. 2016 Jul;37(7):731-9. doi: 10.1093/carcin/bgw056. Epub 2016 May 4. PMID: 27207671 *Co-first authors reflecting equal effort, position reversed from publication order for emphasis
  4. Grimm WA, Messer JS, Murphy SF, Nero T, Lodolce JP, Weber CR, Logsdon MF, Bartulis S, Sylvester BE, Springer A, Dougherty U, Niewold TB, Kupfer SS, Ellis N, Huo D, Bissonnette M, Boone DL. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut. 2015 Feb 2. pii: gutjnl-2014-308735. doi: 10.1136/gutjnl-2014-308735. [Epub ahead of print] PMID:25645662
  5. Messer JS*, Zhu X*, Wang Y, Lin F, Cham CM, Chang J, Billiar TR, Lotze MT, Boone DL, Chang EB. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 2015 Mar 2;125(3):1098-110. doi: 10.1172/JCI76344. Epub 2015 Feb 2. PMID:25642769 *Co-first authors reflecting equal effort, position reversed from publication order for emphasis

More Information

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