Jeannette Messer
Section of Gastroenterology
Instructor of Medicine

Training

DegreeYearInstitutionArea
DVM2001Michigan State UniversityVeterinary Medicine
MS2005Ohio State UniversityVeterinary Clinical Sciences (Comparative Physiology)
Residency2005Ohio State UniversitySmall Animal Internal Medicine
PhD2013The University of ChicagoImmunology

Academic Interests

The Messer Research Group studies the role of gut microbes in chronic inflammatory diseases. Our focus is on identifying disease-causing changes in microbial behavior across the gut microbial community. In particular, we study how virulence is activated in normally commensal gut bacteria and how that virulence contributes to inflammatory bowel diseases, metabolic diseases, and cancers. We have recently discovered a novel mechanism of gut antibacterial defense that specifically targets bacteria expressing virulence, inactivates virulence mechanisms, and turns off expression of that virulence. More importantly, this antibacterial defense system is compromised in active inflammatory bowel disease. We are now working to exploit this innate immune mechanism to identify microbes and microbial behaviors that contribute to epithelial damage during inflammatory bowel disease and develop strategies to target these bacteria and their disease-causing behavior therapeutically.


Representative Publications

  1. Messer JS*, Zhu X*, Wang Y, Lin F, Cham CM, Chang J, Billiar TR, Lotze MT, Boone DL, Chang EB. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 2015 Mar 2;125(3):1098-110. doi: 10.1172/JCI76344. Epub 2015 Feb 2. PMID:25642769 *Co-first authors reflecting equal effort, position reversed from publication order for emphasis
  2. Messer JS*, Murphy SF*, Logsdon MF, Lodolce JP, Grimm WA, Bartulis SJ, Vogel TP, Burn M, Boone DL. The Crohn's disease: associated ATG16L1 variant and Salmonella invasion. BMJ Open. 2013 Jun 20;3(6). doi:pii: e002790. 10.1136/bmjopen-2013-002790. Print 2013. *Co-first authors
  3. Zhai Z, Wu F, Dong F, Chuang AY, Messer JS, Boone DL, Kwon JH. Human autophagy gene ATG16L1 is post-transcriptionally regulated by MIR142-3p. Autophagy. 2014 Jan 6;10(3). [Epub ahead of print] PMID: 24401604
  4. Messer JS*, Tao, Y*, Goss KH, Hart J, Bissonnette M, Chang EB. Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model. Carcinogenesis. 2016 Jul;37(7):731-9. doi: 10.1093/carcin/bgw056. Epub 2016 May 4. PMID: 27207671 *Co-first authors reflecting equal effort, position reversed from publication order for emphasis
  5. Grimm WA, Messer JS, Murphy SF, Nero T, Lodolce JP, Weber CR, Logsdon MF, Bartulis S, Sylvester BE, Springer A, Dougherty U, Niewold TB, Kupfer SS, Ellis N, Huo D, Bissonnette M, Boone DL. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut. 2015 Feb 2. pii: gutjnl-2014-308735. doi: 10.1136/gutjnl-2014-308735. [Epub ahead of print] PMID:25645662



More Information

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