Section of Rheumatology
Associate Professor of Medicine
|PhD||1986||National Institute for Medical Research, London, UK||Genetics
|D.Sc.||1998||Rene Descartes University,Paris||Immunology
Dr. Gounari is interested in signal transduction pathways that are involved in the development of hematopoietic stem cells into the T-cell lineage and deregulations that lead to leukemia. A major focus of research is the pre-T-Cell Receptor, that triggers the expansion and differentiation of immature thymocytes. Her work has demonstrated a cross talk of preTCR signaling with the Wnt/beta-catenin and Notch cascades. Both Wnt/beta-catenin and Notch have been directly linked with human cancer. Dr. Gounari is currently studying the physiological versus pathological interactions of these pathways in developing versus transformed thymocytes.
- Guo Z, Dose M, Kovalovsky D, Chang R, O'Neil J, Look AT, von Boehmer H, Khazaie K, Gounari F. Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood. 109: 5463-72. (2007).
- Dose M., Khan I., Guo Z., Kovalovsky D., Krueger A., von Boehmer H., Khazaie K., and Gounari F. c-Myc mediates preTCR induced proliferation but not developmental progression. Blood 108: 2669- 2677. (2006
- Gounari F., Chang R., Cowan J., Guo Z., Dose M., Gounaris E. & Khazaie K. Loss of the Adenomatous-Polyposis-Coli gene function disrupts thymic development. Nat. Immunol. 6: 800-809. (2005).
- Martin C.H., Aifantis I., Scimone M.L., von Andrian U.H., Reizis B., von Boehmer H., and Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 4: 866-873, (2003).
- Gounari, F., Aifantis, I., Martin, C., Fehling, H.-J., Hoeflinger, S., Leder, P., von Boehmer, H. and Reizis B.
Tracing lymphopoiesis with the aid of a preTCR-a controlled reporter gene. Nature Immunol. 3: 489-495. (2002).