Yu-Ying He
Section of Dermatology
Associate Professor of Medicine

Training

DegreeYearInstitutionArea
BS1995Beijing Institute of PrintingPrinting Technology
PhD2000Chinese Academy of SciencesOrganic Chemistry
Fellowship2001University of Erlangen-NuernbergEnvironmental Biology
Fellowship2007NIEHS/NIHCancer Biology

Academic Interests

Dr. He’s research interests are in the molecular mechanisms in skin carcinogenesis induced by environmental ultraviolet (UV) radiation and the development of chemopreventive and therapeutic strategies to reduce the skin cancer burden. Her current research focuses on identifying previously unrecognized novel molecular/cellular processes that determine susceptibility to skin carcinogenesis. Her laboratory uses molecular, genetic, and translational approaches in cell culture models and clinically relevant animal models to investigate how DNA repair and DNA damage responses of skin cells are regulated in vivo and what their impact is on skin carcinogenesis.


Representative Publications

  1. Ming M, Shea CR, Guo XM, Li XL, Soltani K, Han WN, He YY. Regulation of Global Genome Nucleotide Excision Repair by SIRT1 through xeroderma pigmentosum C. Proc. Natl. Acad. Sci. USA, 107 (2010) 22623-22628.
  2. Ming M, Han WN, Maddox J, Soltani K, Shea CR, Freeman D, He YY. UVB induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes. Oncogene, 29 (2010) 492-502
  3. Han WN, Ming M, He YY. Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. J. Biol. Chem., 286 (2011) 22825-22832
  4. Ming M, Feng L, Shea CR, Soltani K, Zhao B, Han WN, Smart RC, Trempus CS, He YY. PTEN positively regulates UVB-induced DNA damage repair. Cancer Res., 71 (2011) 5287-5295.
  5. Han WN, Ming M, He TC, He YY. Immunosuppressive Cyclosporin A Activates AKT in Keratinocytes through PTEN Suppression: Implications in Skin Carcinogenesis. J. Biol. Chem., 285 (2010) 11369-11377.



More Information

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