Hatim Hassan
Section of Nephrology
Assistant Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730

Training

DegreeYearInstitutionArea
MD1994University of Khartoum Medical School, Khartoum, Sudan 
Residency1996Cairo University Hospitals, EgyptInternal Medicine
Fellowship1999St. Louis UniversityNephrology
Residency2001St. Louis UniversityInternal Medicine
Fellowship2005Yale University School of MedicineNephrology
PhD2007Yale University, New Haven, CTInvestigative Medicine

Academic Interests

Dr. Hassan’s research focuses on elucidating the molecular mechanisms regulating SLC26A6, a key transporter in oxalate homeostasis, and how this regulation might pertain to the risk of hyperoxaluria and calcium oxalate kidney stone disease. Dr. Hassan has found that cholinergic signaling inhibits SLC26A6-mediated oxalate transport by human intestinal T84 cells through signaling pathways including the M3 muscarinic receptor, phospholipase C, PKC-d and c-Src kinase. Ongoing research seeks to test the hypothesis that SLC26A6 activity is under cholinergic regulation in the intestine, and that changes in cholinergic (vagal) tone may thereby affect oxalate homeostasis, urinary oxalate excretion, and stone risk. His lab is also studying the roles of purinergic and serotonergic signaling, acting through PKC-d, in the regulation of intestinal oxalate transport and how these signaling pathways might pertain to the risk of hyperoxaluria and calcium oxalate kidney stone disease. Using a diversity of cultured mammalian cells and whole animals, ongoing research utilizes a variety of techniques, including immunoblotting, immunoprecipitaion, cloning, real time PCR, site-directed mutagenesis, confocal microscopy, genomic approaches, and flux studies in cells and native intestinal tissues mounted in Ussing chambers (including measurements of paracellular permeability).


Clinical Interests

Fluid and electrolyte and acid-base disorders, Kidney stones, and acute renal failure.


Representative Publications

  1. Hassan, H.A., Mentone, S., Karniski, L.P., Rajendran, V.M., and Aronson, P.S. Regulation of anion exchanger Slc26a6 by protein kinase C. Am. J. Physiol. 292:C1485-C1492, 2007.
  2. Hassan, H.A. (2007). Mechanisms of Regulation of Anion Exchanger Slc26a6. Retrieved from Dissertations and Theses database. (AAT 3267262).
  3. Kahle, K., Gimenez, I., Hassan H.A., Wilson, F., Wong, R., Forbush, B., Aronson, P.S., and Lifton, R. WNK4 regulates apical and basolateral Cl flux in extrarenal epithelia. Proc. Natl. Acad. Sci. 101:2064-2069, 2004.
  4. Disthabanchong, S., Hassan, H.A., McConkey, C., Martin, K.J., and Gonzalez, E.A. Regulation of PTH1 receptor expression by uremic ultrafiltrate in UMR 106-01osteoblast-like cells. Kidney Int. 65(3):897-903, 2004.
  5. Gonzalez, E.A., Hassan, H.A., and Martin, K.J. Divalent ion regulation and disorders. In Textbook of Clinical Nephrology, Dialysis and Transplantation. H.H. Mulluche et al, eds. Dustri-Verlag, Munich. Vol 1 (1.5): 1-36



More Information

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