Philip Verhoef
Section of Pulmonary / Critical Care
Assistant Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730


PhD2004Case Western Reserve UniversityPharmacology
MD2005Case Western Reserve UniversityMedicine
Residency2009University of California-Los AngelesCombined Internal Medicine and Pediatrics
Fellowship2014The University of ChicagoAdult and Pediatric Critical Care

Academic Interests

Dr. Verhoef studies the innate immune response in mediating diseases often encountered in the ICU. During his post-doctoral training in Albert Bendelac’s lab, he focused on the role of a novel cell type termed the innate lymphoid cell in mediating type 2 inflammation in mice. He is now building a research program focused on the hypothesis that innate responses play a critical role in the acute septic inflammatory response. In addition, he is focusing on the role of the type 2 immune response as a mediator of protection against mortality in sepsis. He uses mouse models of disease, as well as human translational and big data approaches to address these questions.

Clinical Interests

Med-Peds critical care, congenital heart disease in the adult ICU, sepsis, inflammation.

Representative Publications

  1. Verhoef PA, Kertesy SB, Lundberg K, Kahlenberg JM, and Dubyak GR (2005). “Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1Beta Secretion, and Cytolysis by the P2X7 Receptor.” J Immunol 175(11): 7623-34. PMID: 16301672
  2. Halfon, N, Verhoef PA, and Kuo AA, (2012) “Childhood Antecedents to Adult Disease,” Pediatr Rev 33(2), 1-10. PMID: 22301031
  3. Mahajan AK, Patel SB, Verhoef P, Carr GE, Hogarth DK. (2012) "Intrabronchial Valves (IBV): A Case Series Describing a Minimally Invasive Approach to Bronchopleural Fistulas (BPF) in Medical Intensive Care Unit (MICU) Patients.” J Bronchol Intervent Pulmonol. 19(2):137-141 PMID: 23207358
  4. Verhoef PA, (2013) “Meeting Meaningful Use Criteria and Managing Patient Populations,” Ann Intern Med 159(10): 717-8. PMID: 24247680
  5. Constantinides MG, McDonald BD, Verhoef PA, Bendelac A. (2014) “A Committed Precursor to Innate Lymphoid Cells.” Nature. 508: 397-401. PMID: 24509713

More Information

For more information about Dr. Philip Verhoef publications and research collaborations , please click here