Philip Verhoef
Section of Pulmonary / Critical Care
Assistant Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730


PhD2004Case Western Reserve UniversityPharmacology
MD2005Case Western Reserve UniversityMedicine
Residency2009University of California-Los AngelesCombined Internal Medicine and Pediatrics
Fellowship2014The University of ChicagoAdult and Pediatric Critical Care

Academic Interests

Dr. Verhoef is a physician-scientist interested in immune dysfunction in the ICU. His K08-funded research focuses on the hypothesis that type 2 (allergic) immunity plays a critical pro-resolving, anti-inflammatory role during acute infection. His laboratory employs the entire spectrum of basic, translational, informatic, and clinical approaches. First, he uses mouse models of Staphylococcus aureus sepsis to understand how type 2 immunity protects against sepsis lethality; second, he is continuing a project started by fellowship graduate Jared Greenberg (now at Rush University) in which blood from septic patients with Staphylococcus aureus bacteremia is collected at various time points and analyzed for markers of immune function; and finally, in collaboration with Medicine faculty like Matthew Churpek and Andrey Rzhetsky, he is analyzing large electronic datasets to understand how the presence of comorbid immunologic diseases modifies the course of infection and sepsis. His long term objective is to bring rigorous immunologic analysis to the care of critically ill patients.

Clinical Interests

Med-Peds critical care, congenital heart disease in the adult ICU, sepsis, inflammation.

Representative Publications

  1. Mahajan AK, Patel SB, Verhoef P, Carr GE, Hogarth DK. (2012) "Intrabronchial Valves (IBV): A Case Series Describing a Minimally Invasive Approach to Bronchopleural Fistulas (BPF) in Medical Intensive Care Unit (MICU) Patients.” J Bronchol Intervent Pulmonol. 19(2):137-141 PMID: 23207358
  2. Verhoef PA, (2013) “Meeting Meaningful Use Criteria and Managing Patient Populations,” Ann Intern Med 159(10): 717-8. PMID: 24247680
  3. Constantinides MG, McDonald BD, Verhoef PA, Bendelac A. (2014) “A Committed Precursor to Innate Lymphoid Cells.” Nature. 508: 397-401. PMID: 24509713
  4. Verhoef PA, Kertesy SB, Lundberg K, Kahlenberg JM, and Dubyak GR (2005). “Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1Beta Secretion, and Cytolysis by the P2X7 Receptor.” J Immunol 175(11): 7623-34. PMID: 16301672
  5. Halfon, N, Verhoef PA, and Kuo AA, (2012) “Childhood Antecedents to Adult Disease,” Pediatr Rev 33(2), 1-10. PMID: 22301031

More Information

For more information about Dr. Philip Verhoef publications and research collaborations , please click here