Section of Pulmonary / Critical Care
Assistant Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730
|PhD||2004||Case Western Reserve University||Pharmacology
|MD||2005||Case Western Reserve University||Medicine
|Residency||2009||University of California-Los Angeles||Combined Internal Medicine and Pediatrics
|Fellowship||2014||The University of Chicago||Adult and Pediatric Critical Care
Dr. Verhoef studies the innate immune response in mediating diseases often encountered in the ICU. During his post-doctoral training in Albert Bendelac’s lab, he focused on the role of a novel cell type termed the innate lymphoid cell in mediating type 2 inflammation in mice. He is now building a research program focused on the hypothesis that innate responses play a critical role in the acute septic inflammatory response. In addition, he is focusing on the role of the type 2 immune response as a mediator of protection against mortality in sepsis. He uses mouse models of disease, as well as human translational and big data approaches to address these questions.
Med-Peds critical care, congenital heart disease in the adult ICU, sepsis, inflammation.
- Verhoef PA, Kertesy SB, Lundberg K, Kahlenberg JM, and Dubyak GR (2005). “Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1Beta Secretion, and Cytolysis by the P2X7 Receptor.” J Immunol 175(11): 7623-34. PMID: 16301672
- Halfon, N, Verhoef PA, and Kuo AA, (2012) “Childhood Antecedents to Adult Disease,” Pediatr Rev 33(2), 1-10. PMID: 22301031
- Mahajan AK, Patel SB, Verhoef P, Carr GE, Hogarth DK. (2012) "Intrabronchial Valves (IBV): A Case Series Describing a Minimally Invasive Approach to Bronchopleural Fistulas (BPF) in Medical Intensive Care Unit (MICU) Patients.” J Bronchol Intervent Pulmonol. 19(2):137-141 PMID: 23207358
- Verhoef PA, (2013) “Meeting Meaningful Use Criteria and Managing Patient Populations,” Ann Intern Med 159(10): 717-8. PMID: 24247680
- Constantinides MG, McDonald BD, Verhoef PA, Bendelac A. (2014) “A Committed Precursor to Innate Lymphoid Cells.” Nature. 508: 397-401. PMID: 24509713