Susan Sam
Section of Endocrinology, Diabetes and Metabolism
Assistant Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730


MD1995University of Illinois at Chicago 
Residency1998Northwestern UniversityInternal Medicine
MS2003Northwestern University Graduate SchoolClinical Investigation
Fellowship2003Northwestern University Feinberg School of MedicineEndocrinology, Metabolism, and Molecular Medicine

Academic Interests

Dr. Sam’s research focuses on metabolic abnormalities associated with polycystic ovary syndrome (PCOS). In particular she is interested in the role of adipose tissue on development of insulin resistance and metabolic disorders in PCOS. Dr. Sam’s previous work has shown that PCOS predisposes to abdominal obesity and inflammation in the fat. She continues ongoing work in this area to elucidate the mechanisms for the abnormalities that predispose to insulin resistance.

Clinical Interests

PCOS, type 1 and 2 diabetes, thyroid disorders, pituitary disorders, other reproductive disorders such as premature ovarian failure and hypothalamic amenorrhea

Representative Publications

  1. Sam S, Mazzone T. 2014. Adipose tissue changes in obesity and the impact on metabolic function. Transl Res. S1931-5244(14)
  2. Huang ZH, Manickam B, Ryvkin V, Zhou Xiaohong Joe, Fantuzzi G, Mazzone T, and Sam S. 2013. PCOS is associated with increased CD11c expression and crown Like Structures in adipose tissue and increased central abdominal fat depots independent of obesity. J Clin Endocrinol and Metab 98: E17-24.
  3. Mokhlesi B, Scoccia B, Mazzone T, Sam S. 2012. Risk of Obstructive Sleep Apnea in Obese and Nonobese Women with Polycystic Ovary Syndrome and Healthy Reproductively Normal Women. Fertil Steril 97: 786-791.
  4. Sidhwani, S, Scoccia, B, Sunghay, S, Stephens-Archer, CN, Mazzone, T & Sam S. 2011. PCOS is associated with atherogenic changes in lipoprotein particle number and size independent of body weight. Clin Endocrinol 75:76-82. NIHSID: NIHMS273639
  5. Sam S, Legro RS, Dunaif A. 2006. Evidence for heritable changes in metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome. Proc Natl Acad Sci U S A 103:7030-7035.

More Information

For more information about Dr. Susan Sam publications and research collaborations , please click here