Yoav Gilad
Section of Genetic Medicine
Professor of Medicine
Chief, Section of Genetic Medicine

Training

DegreeYearInstitutionArea
M.Sc2000Weizmann InstituteMolecular Genetics
PhD2003Weizmann Institute of ScienceMolecular Genetics
Fellowship2005Yale UniversityGenetics

Academic Interests

Dr. Gilad is a highly regarded and internationally acclaimed leader in the fields of human genetics, gene regulation, and genome biology .He is a molecular geneticist whose research focuses on advancing our understanding of the genetics of complex phenotypes by studying intermediate molecular data, such as gene regulatory states within and across populations and species. Dr. Gilad uses both human and non-human primate models to understand how changes in gene regulation can explain human diseases, and how individual cells vary and differ from each other. Understanding this variability has profound impact on our understanding of how organs and our whole body function as a unit, and may help in defining what genetic differences are truly relevant to the development of common diseases. Dr. Gilad’s lab uses innovative empirical and computational approaches, such as stem cell models, single-cell sequencing, genome informatics, and functional genomics tools, using both human and non-human primate cells and tissues in order to advance individualized medicine


Representative Publications

  1. Yang IL, van de Geijn B, Raj A, Knowles DA, Petti AA, Golan D, Gilad Y, and Pritchard JK. RNA splicing is a primary link between genetic variation and disease. Science 2016 Apr 29; 352(6285): 600-604. doi: 10.1126/science.aad9417
  2. Khan Z, Ford MJ, Cusanovich DA, Mitrano A, Pritchard JK, and Gilad Y. Primate Transcript and Protein Expression Levels Evolve under Compensatory Selection Pressures. Science 2013 Oct 17. [Epub ahead of print
  3. Battle A, Kahn Z, Wang SH, Mitrano A, Ford MJ, Pritchard JK, and Gilad Y. Impact of regulatory variation from RNA to protein. Science. 2014 Dec 18.
  4. Tung J, Barreiro LB, Johnson ZP, Hansen KD, Michopoulos M, Toufexis T, Michelini K, Wilson ME, and Gilad Y. Social environment is associated with gene regulatory variation in the rhesus macaque immune system. PNAS 2012 Apr 24;109(17):6490-5.
  5. Gallego Romero I, Pavlovic BJ, Hernando-Herraez I, Zhou X, Ward MC, Banovich NE, Kagan CL, Burnett JE, Huang CH, Mitrano A, Chavarria CI, Friedrich Ben-Nun I, Li Y, Sabatini K, Leonardo TR, Parast M, Marques-Bonet T, Laurent LC, Loring JF, and Gilad Y. A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics. Elife. 2015 Jun 23;4. doi: 10.7554/eLife.07103.



More Information

For more information about Dr. Yoav Gilad publications and research collaborations , please click here