Manami Hara
Section of Endocrinology, Diabetes and Metabolism
Research Associate (Associate Professor)


DDS1990Kyushu UniversityOral Surgery
PhD1994Kyushu UniversityDentistry

Academic Interests

Dr. Hara's research focuses on the identification and characterization of the cells that define the lineage that gives rise to the pancreatic beta cell. She has generated a series of lines of transgenic mice expressing various fluorescent proteins under the control of a series of transcription factor and other promoters that characterize different cell types in the beta cell lineage. She is using these genetically tagged cells to define the patterns of gene expression that characterize each cell type. These studies may lead to the identification of the stem cell that gives rise to the pancreatic beta cell and thereby open up new avenues for treating diabetes.

Representative Publications

  1. Hara, M., Yin, D., Dizon, R.F., Shen, J., Chong, A.S., and Bindokas V.P. A mouse model for studying intrahepatic islet transplantation. Transplantation 78: 615-618, 2004
  2. Hara, M., Bindokas, V.P., Lopez, J., Kaihara, K., Landa Jr., L.R., Harbeck, M., and Roe M.W. Transgenic expression of a fluorescent calcium biosensor in mice. Am. J. Physiol. Cell Physiol. 287: C932-938, 2004
  3. Alcoser S.Y., Hara, M., and Ehrmann, D.A. Association of the ARE polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 89: 2973-2976, 2004
  4. Reutrakul, S., Hathout E.H., Janner, D., Hara, M., Donfack, J., and Refetoff S. Familial juvenile autoimmune hypothyroidism, pituitary enlargement, obesity and insulin resistance. Thyroid. 14:311-319, 20
  5. Kojima, H., Fujimiya, M., Matsumura, K., Nakahara, T., Hara, M., Chan, L. Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc. Natl. Acad. Sci. USA 101: 2458-2463, 2004.

More Information

For more information about Dr. Manami Hara publications and research collaborations , please click here