Fredric Coe
Section of Nephrology
Professor of Medicine
Co-Director, Kidney Stone Program; Director, Clinical Research Training Program
Referring Physician Access Line: 1-877-DOM-2730


BA1955The University of Chicago 
BS1957The University of ChicagoPhysiology
MD1961The University of Chicago 
Residency1964Michael Reese HospitalMedicine
Residency1965Michael Reese HospitalChief Resident
Fellowship1969University of TexasNephrology

Academic Interests

Dr. Coe's laboratory studies the pathogenesis and treatment of kidney stones. Dr. Coe has mined data from an extensive database of laboratory and clinical materials collected over 30 years that has helped create a coherent sense of the disease for physicians throughout the world. His current human protocols are aimed at understanding the pathogenesis of genetic hypercalciuria and naturally occurring inhibitors of crystallization in kidneys and urine. Animal experiments have led to the development of a promising model of enteric hyperoxaluria with nephrocalcinosis and an inbred strain of hypercalciuric, stone-forming rats that exhibit abnormal vitamin D-receptor abundance in the intestine, kidney, and bone.

Clinical Interests

Prevention and treatment of kidney stones

Representative Publications

  1. Matlaga BR, Miller NL, Terry C et al.: The pathogenesis of calyceal diverticular calculi. Urol Res 35:35-40, 2007
  2. Evan AP, Lingeman J, Coe F et al.: Renal histopathology of stone-forming patients with distal renal tubular acidosis. Kidney Int 71:795-801, 2007
  3. Asplin JR, Coe FL: Hyperoxaluria in kidney stone formers treated with modern bariatric surgery. J Urol 177:565-569, 2007
  4. Worcester EM, Gillen DL, Evan AP et al.: Evidence that postprandial reduction of renal calcium reabsorption mediates hypercalciuria of patients with calcium nephrolithiasis. Am J Physiol Renal Physiol 292:F66-F75, 2007
  5. Matlaga BR, Coe FL, Evan AP, Lingeman JE: The role of Randall's plaques in the pathogenesis of calcium stones. J Urol 177:31-38, 2007

More Information

For more information about Dr. Fredric Coe publications and research collaborations , please click here