Dianne Deplewski
Section of Endocrinology, Diabetes and Metabolism
Associate Professor of Medicine

Training

DegreeYearInstitutionArea
BS1982Northwestern U.Biochemistry
MD1986U. IllinoisMedicine

Academic Interests

Dr. Deplewski is studying the biologic and molecular basis of the growth of the sebaceous gland, using the rat preputial gland as a model. She examines the effects of retinoic acid analogs and androgens on the growth of preputial cells in culture and the effect of the stromal-epithelial interface on the growth and ultrastructure of sebaceous cells in monolayer and lifted-raft culture. She examines the expression of 5?-reductase in sebaceous cells the peroxisomal proliferator activated receptors in sebaceous cells, which is a focus of the grant in which she is a co-investigator. Future directions of research are to further studies on the role of GH and IGFs in preputial cell growth and development. Specifically, she will attempt to delineate the direct and indirect effect of GH in the sebaceous gland system by utilizing antibodies against IGFs, and by measuring the levels of the IGFs and IGF binding proteins in cell culture media.


Clinical Interests

Pediatric endocrinology


Representative Publications

  1. Littlejohn EE, Weiss RE, Deplewski D, Edidin DV, Rosenfield RL. Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndrome. J Pediatr Endocrinol Metab, 20:41-51, 2007
  2. Schmuth M, Watson EEB, Deplewski D, Dubrac S, Zouboulis CC, Griffiths CEM. Nuclear hormone receptors in human skin. Horm Metab Res 39:96-105, 2007.
  3. Deplewski D. “Obesity in Children”, BMJ Point of Care Monograph, www.pointofcare.bmj.com.,2009; updated 2010.
  4. Deplewski D. "Endocrinology." Pediatric Examination and Board Review. Jason Canal and Robert Daum eds., 2nd edition, McGraw-Hill, in press, 2011.
  5. 4. Reshmi SC, Miller JL, Deplewski D, Henderson LJ, Littlejohn E, Waggoner DJ, Schwartz S. Evidence of a mechanism for isodicentric chromosome Y formation in a 45,X/46,del(Y)(p11.2)/46,X,idic(Y)(p11.2) mosaic karyotype. European Journal of Medical Genetics, in press 2010.



More Information

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