Silvana Pannain
Section of Endocrinology, Diabetes and Metabolism
Associate Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730


MD1990Universita degli Studi di Napoli 
Residency2002Montefiore Medical CenterInternal Medicine
Fellowship2004The University of ChicagoEndocrinology and Metabolism

Academic Interests

The main focus of Dr. Pannain’s research is to examine the metabolic and endocrine aspects of chronic partial sleep loss as a putative risk factor for obesity, insulin resistance and accelerated metabolic aging. In this regard she is currently testing the hypothesis that “paying the sleep debt” in subjects with impaired glucose tolerance (IGT) or type-2 diabetes (DM2) and habitual sleep curtailment will improve glucose metabolism. Dr Pannain is also interested in studying the correlation between chronic sleepiness, glucose metabolism and appetite regulation in obesity and the effect of gastric bypass surgery on metabolism, sleep and hunger.

Clinical Interests

General endocrinology with a specific interest in type I diabetes.

Representative Publications

  1. S. Pannain, M. Feldman, U. Eiholzer, R.E. Weiss, NH Scherberg, S. Refetoff. Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for T4. Journal of Clinical Endocrinology and Metabolism, vol. 85, 2786-2792, 2000 (August).
  2. S. Reutrakul, S. Pannain P. M. Sadow, , J. Pohlenz, G. A. Carvalho, P. E. Macchia, R. E. Weiss, S. Refetoff. Search for abnormalities of nuclear corepressors, coactivators and a coregulator in families with resistance to thyroid hormone receptor beta or alpha genes. Journal of Clinical Endocrinology and Metabolism, vol. 85, No. 10, 3609-3617, 2000 (October).
  3. J. Pohlenz, RE Weiss, PE Macchia, S. Pannain, IT Lau, H. Ho, S. Refetoff. Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor beta genes. Journal of Clinical Endocrinology and Metabolism, vol.82, 3919-3928, 1999 (November).
  4. S. Pannain, R.E. Weiss, C.E. Jackson, D.Dian, J.C.Beck, V.C. Sheffield, N. Cox, G.I. Bell , S. Refetoff. Two different mutations in the thyroid peroxidase gene complicate linkage analysis in a large inbred Amish kindred. Journal of Clinical Endocrinology and Metabolism, vol.84, No 12, 1061-1071, 1999 (March).
  5. D. Tiosano, S. Pannain, G. Vassart, J. Parma, R. Gershoni-Baruch, H. Mandel, R. Lotan, Y. Zaharan, M. Pery, S. Refetoff, Z. Hochberg. The hypothyroidism in an inbred kindred with congenital thyroid hormone and glucocorticoid deficiency due to a mutation producing a truncated thyrotropin receptor. Thyroid, vol. 9, 887-894, 1999 (September).

More Information

For more information about Dr. Silvana Pannain publications and research collaborations , please click here