Silvana Pannain
Section of Endocrinology, Diabetes and Metabolism
Associate Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730


MD1990Universita degli Studi di Napoli 
Residency2002Montefiore Medical CenterInternal Medicine
Fellowship2004The University of ChicagoEndocrinology and Metabolism

Academic Interests

Dr Pannain's clinical and research interests include obesity; the metabolic syndrome, and related health conditions such as obstructive sleep apnea and diabetes. Specifically her clinical interest has been to develop Chicago Weight, an interdisciplinary weight loss program and support group at the University of Chicago. In her research, Dr Pannain has investigated the metabolic and endocrine aspects of chronic partial sleep loss, and has recently expanded on those research questions by analyzing sleep patterns of obese subjects and their relationship to metabolic, depression, and quality of life measures.

Clinical Interests

General endocrinology with a specific interest in type I diabetes.

Representative Publications

  1. S. Reutrakul, S. Pannain P. M. Sadow, , J. Pohlenz, G. A. Carvalho, P. E. Macchia, R. E. Weiss, S. Refetoff. Search for abnormalities of nuclear corepressors, coactivators and a coregulator in families with resistance to thyroid hormone receptor beta or alpha genes. Journal of Clinical Endocrinology and Metabolism, vol. 85, No. 10, 3609-3617, 2000 (October).
  2. J. Pohlenz, RE Weiss, PE Macchia, S. Pannain, IT Lau, H. Ho, S. Refetoff. Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor beta genes. Journal of Clinical Endocrinology and Metabolism, vol.82, 3919-3928, 1999 (November).
  3. S. Pannain, R.E. Weiss, C.E. Jackson, D.Dian, J.C.Beck, V.C. Sheffield, N. Cox, G.I. Bell , S. Refetoff. Two different mutations in the thyroid peroxidase gene complicate linkage analysis in a large inbred Amish kindred. Journal of Clinical Endocrinology and Metabolism, vol.84, No 12, 1061-1071, 1999 (March).
  4. D. Tiosano, S. Pannain, G. Vassart, J. Parma, R. Gershoni-Baruch, H. Mandel, R. Lotan, Y. Zaharan, M. Pery, S. Refetoff, Z. Hochberg. The hypothyroidism in an inbred kindred with congenital thyroid hormone and glucocorticoid deficiency due to a mutation producing a truncated thyrotropin receptor. Thyroid, vol. 9, 887-894, 1999 (September).
  5. S. Pannain, M. Feldman, U. Eiholzer, R.E. Weiss, NH Scherberg, S. Refetoff. Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for T4. Journal of Clinical Endocrinology and Metabolism, vol. 85, 2786-2792, 2000 (August).

More Information

For more information about Dr. Silvana Pannain publications and research collaborations , please click here