Murray Favus
Section of Endocrinology, Diabetes and Metabolism
Professor of Medicine
Head, Metabolic Bone Disease Unit
Referring Physician Access Line: 1-877-DOM-2730


BS1963University of IllinoisBiology
MD1967The University of Chicago 
Residency1970Cleveland ClinicMedicine
Fellowship1973Beth Israel HospitalEndocrinology & Gastroenterology
Fellowship1973Harvard UniversityEndocrinology

Academic Interests

Dr. Favus' work focuses on the pathogenesis of hypercalciuric states and the relation of hypercalciuria to low bone mass and osteoporosis. Basic studies in genetic hypercalciuric rats and clinical studies in patients with genetic idiopathic hypercalciuria are the major areas of investigation. Clinical studies in osteoporosis are also conducted. In the area of calcium metabolism, Dr. Favus has identified increases in intestinal, kidney, and bone vitamin D receptor content in genetic hypercalciuric kidney stone forming rats, an animal model of human idiopathic hypercalciuria. This description represents one of the first examples of a disorder (hypercalciuria, stone formation, and low bone mass) caused by a pathologic excess of a steroid hormone. Of particular interest is the role of the estrogen receptor and the vitamin D receptor in the regulation of expression of genes involved in renal calcium transport and the control of hypercalciuria. In clinical studies of osteoporosis, Dr. Favus evaluates the role of hypercalciuria in bone loss and in the use of risk factors to predict fracture risk in postmenopausal women.

Clinical Interests

Osteoporosis and related metabolic bone diseases, parathyroid disorders, and calcium nephrolithiasis.

Representative Publications

  1. Yao, Y., Kathpalia, P., Bushinsky, D.A., Favus, M.J. Hyper-responsiveness of vitamin D receptor gene expression to 1,25-dihydroxyvitamin D3: A new characteristic of genetic hypercalciuric stone-forming rats. J. Clin. Invest., 101:2223-2232,1998.
  2. Caligiuri, P., Giger, M.L., and M.J. Favus. Multifractal radiographic analysis of osteoporosis. Med. Phys. 21:503-508, 1994.
  3. Favus, M.J., Mangelsdorf D.J., Tembe, V., Coe, B.J., and Haussler, M.R. Evidence for in vivo up regulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat. J. Clin. Invest. 82:218_224, 1988.
  4. Coe, F.L., Favus, M.J., Crockett, T., Strauss, A.L., Parks, J.H., Porat, A., Gantt, C.L., and Sherwood, L.M., Effects of low calcium diet on urine calcium excretion, parathyroid function and serum 1,25(OH)2D3 levels in patients with idiopathic hypercalciuria and normal subjects. Am. J. Med. 72:25_32, 1982.
  5. Favus, M.J., Schneider, A.B., Stachura, M.E., Arnold, J.E., Ryo, U.Y., Pinsky, S.M., Colman, J., Arnold, M.J., and Frohman, L.A., Thyroid cancer occurring as a late consequence of head and neck irradiation: Evaluation of 1056 patients. New Engl. J. Med. 294:1019_1025, 1976

More Information

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