Section of Rheumatology
Professor of Medicine
Chief, Section of Rheumatology; Director, Medical Scientist Training Program
Referring Physician Access Line: 1-877-DOM-2730
|BS||1980||University of California||Biomedical Sciences
|MD||1984||University of California Los Angeles||
|Residency||1987||University of Michigan||Internal Medicine
|Fellowship||1990||University of California||Rheumatology
Dr. Clark is interested in the molecular mechanisms by which signals initiated by the B cell antigen receptor contribute to B lymphocyte biological responses including, B cell development, B cell selection and receptor trafficing. He is also interested in how signals through the T cell antigen receptor can be manipulated to induce energy.
Treatment of rheumatoid arthritis and psoriatic arthritis.
- Zhang M, Massenburg D, and Clark MR. 2004 BCR signaling requirements for targeting of antigen to the MHC class II processing pathway. In press, Curr. Opin Immunology.
- Wang LD, Lopes J, Cooper AB, Dang-Lawson M, Matsuuchi L and Clark MR. 2004. Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor. Proc. Natl. Acad. Sci. 101:1027-1032.
- Sun T, Clark MR, and Storb U. 2002. A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. Immunity 16(2):245-256.
- Kabak S, Skaggs B, Gold MR, Affolter M, West K, Foster M, Siemasko K, Chan AC, Aebersold R and Clark MR. 2002. The direct recruitment of BLNK to Iga couples the BCR to distal signaling pathways. Mol. Cell. Biol. 22:2524-2535.
- Siemasko K, Skaggs B, Kabak S, Williamson E, Brown B, Song W and Clark MR. 2002. Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Iga. J. Immunol. 168:2127-2138