Marcus Clark
Section of Rheumatology
Professor of Medicine
Chief, Section of Rheumatology; Director, Medical Scientist Training Program
Referring Physician Access Line: 1-877-DOM-2730


BS1980University of CaliforniaBiomedical Sciences
MD1984University of California Los Angeles 
Residency1987University of MichiganInternal Medicine
Fellowship1990University of CaliforniaRheumatology

Academic Interests

Dr. Clark is interested in the molecular mechanisms by which signals initiated by the B cell antigen receptor contribute to B lymphocyte biological responses including, B cell development, B cell selection and receptor trafficing. He is also interested in how signals through the T cell antigen receptor can be manipulated to induce energy.

Clinical Interests

Treatment of rheumatoid arthritis and psoriatic arthritis.

Representative Publications

  1. Zhang M, Massenburg D, and Clark MR. 2004 BCR signaling requirements for targeting of antigen to the MHC class II processing pathway. In press, Curr. Opin Immunology.
  2. Wang LD, Lopes J, Cooper AB, Dang-Lawson M, Matsuuchi L and Clark MR. 2004. Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor. Proc. Natl. Acad. Sci. 101:1027-1032.
  3. Sun T, Clark MR, and Storb U. 2002. A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. Immunity 16(2):245-256.
  4. Kabak S, Skaggs B, Gold MR, Affolter M, West K, Foster M, Siemasko K, Chan AC, Aebersold R and Clark MR. 2002. The direct recruitment of BLNK to Iga couples the BCR to distal signaling pathways. Mol. Cell. Biol. 22:2524-2535.
  5. Siemasko K, Skaggs B, Kabak S, Williamson E, Brown B, Song W and Clark MR. 2002. Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Iga. J. Immunol. 168:2127-2138

More Information

For more information about Dr. Marcus Clark publications and research collaborations , please click here