Louis Philipson
Section of Endocrinology, Diabetes and Metabolism
Professor of Medicine
Director,Kovler Diabetes Center
Referring Physician Access Line: 1-877-DOM-2730

Training

DegreeYearInstitutionArea
BA1976Harvard UniversityBiochemistry
PhD1982The University of ChicagoBiochemistry
MD1986The University of Chicago 
Residency1990The University of ChicagoInternal Medicine
Fellowship1991The University of ChicagoEndocrinology, Diabetes and Metabolism

Academic Interests

Dr. Louis Philipson is a leading world authority on diabetes mellitus, and his research focuses on the biophysical, molecular and genetic aspects of insulin secretion, and monogenic diabetes. He was a co-discoverer of insulin gene mutations causing neonatal diabetes, a novel class of mutations causing diabetes through beta cell ER stress. These mutations are now known to be the second most common cause of permanent neonatal diabetes as well as rare causes of later onset diabetes. Dr. Philipson, together with his colleagues Drs Bell, Greeley and Naylor, is a resource for monogenic diabetes in the United States, following more than 100 patients diagnosed with neonatal diabetes and several hundred with MODY type diabetes. The team has also recently established the first United States registry for neonatal and monogenic diabetes. Dr. Philipson is co-director of the Human Islet Transplantation project at the University of Chicago. He has served as principal investigator on numerous research projects and has been widely published in biomedical journals including the Proceedings of the National Academy of Sciences, Science, Nature, Diabetes, American Journal of Physiology and the Journal of Biological Chemistry. Clinically he focuses on type 1 diabetes and complicated type 2 diabetes, monogenic diabetes and hypoglycemia. Currently President of the Chicago/Northern Illinois board of the American Diabetes Association and also a member of its National Board, he has been an invited speaker and presenter at scientific research conferences and symposia worldwide.


Clinical Interests

Diabetes, hypoglycemia, transplantation, and general endocrinology.


Representative Publications

  1. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J.
  2. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J.
  3. Tamarina NA, Roe MW, Philipson LH. Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic ß-cells Islets, 2014 vol. 6 (1).
  4. Visualizing superoxide production in normal and diabetic rat islets of Langerhans. KS Polonsky, MW Roe, LH Philipson - Journal of Biological, 2003 - ASBMB
  5. Naylor R, PHILIPSON LH. Who should have genetic testing for maturity-onset diabetes of the young? Clinical Endocrinology, 2011 vol. 75 (4) pp. 422-426.



More Information

For more information about Dr. Louis Philipson publications and research collaborations , please click here