Louis Philipson
Section of Endocrinology, Diabetes and Metabolism
Professor of Medicine
Director,Kovler Diabetes Center
Referring Physician Access Line: 1-877-DOM-2730

Training

DegreeYearInstitutionArea
BA1976Harvard UniversityBiochemistry
PhD1982The University of ChicagoBiochemistry
MD1986The University of Chicago 
Residency1990The University of ChicagoInternal Medicine
Fellowship1991The University of ChicagoEndocrinology, Diabetes and Metabolism

Academic Interests

Dr. Philipson’s research focuses on how pancreatic Beta-cells “know” when to secrete insulin and define defects in this process in diabetes that could be therapeutic targets. His focus is the study of ion channels, metabolism, and mitochondria that together regulate intracellular calcium concentration and energy production and thereby regulate insulin secretion in pancreatic islet Beta-cells. He is studying such processes as exocytosis of single insulin granules and production of reactive oxygen species in normal and diabetic mice and in human islets.


Clinical Interests

Diabetes, hypoglycemia, transplantation, and general endocrinology.


Representative Publications

  1. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J.
  2. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J.
  3. Tamarina NA, Roe MW, Philipson LH. Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic ß-cells Islets, 2014 vol. 6 (1).
  4. Visualizing superoxide production in normal and diabetic rat islets of Langerhans. KS Polonsky, MW Roe, LH Philipson - Journal of Biological, 2003 - ASBMB
  5. Naylor R, PHILIPSON LH. Who should have genetic testing for maturity-onset diabetes of the young? Clinical Endocrinology, 2011 vol. 75 (4) pp. 422-426.



More Information

For more information about Dr. Louis Philipson publications and research collaborations , please click here