Section of Hematology / Oncology
Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730
|BA||1982||Brown University||Political Science
|MS||1985||University of London||Immunology
|Residency||1990||Cornell University||Internal Medicine
|Fellowship||1993||Dartmouth-Hitchcock Medical Center||Hematology/Oncology
|Fellowship||1996||Howard Hughes Medical Institute||Molecular Virology
|Fellowship||1998||The University of Chicago||Molecular Oncology
Dr. Conzen's laboratory uses both molecular approaches and animal models to study mechanisms that contribute to the development and progression of human breast cancer. Current projects include 1) defining glucocorticoid receptor signaling pathways in breast epithelium, 2) determining the role of ubiquitin modification of cellular kinases in breast cancer survival signaling pathways and 3) using bioinformatic approaches to predict signaling pathways from large-scale time course microarray data.
Locally advanced breast cancer
- Wu W, Chaudhuri S, Brickley DR, Pang D, Karrison T, Conzen SD. Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res. 2004; 64(5):1757-64.
- Poelman SM, Heimann R, Fleming GF, Recant WM, Conzen SD. Invariant p53 immunostaining in primary and recurrent breast cancer. Eur J Cancer. 2004; 40(1):28-32.
- Brickley DR, Mikosz CA, Hagan CR, Conzen SD.Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1).J Biol Chem. 2002; 277(45):43064-70.
- Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem. 2001; 276(20):16649-54.
- Moran TJ, Gray S, Mikosz CA, Conzen SD. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res. 2000; 60(4):867-72.