Tipu Puri
Section of Nephrology
Associate Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730


BA1989Northwestern UniversityBiochemistry and Molecular Biology
PhD1997Northwestern UniversityPharmacology and Toxicology
MD1999Northwestern University 
Residency2001University of ChicagoInternal Medicine
Fellowship2004The University of ChicagoNephrology

Academic Interests

Dr.Puri studies the pathogenesis of renal fibrosis and progression of renal disease. It is widely held that chronic kidney diseases such as diabetic, hypertensive, and other nephropathies, progress through a final common pathway resulting in fibrosis and culminating in end stage renal disease. His current work is focused on developing a novel animal model in which to apply microarray techniques to identify genetic factors that confer susceptibility or resistance to more rapid progression of renal disease. In vitro models of key mediators of renal fibrosis are also being developed in which to further study factors identified by animal studies.

Clinical Interests

Progression of chronic kidney diseases, hypertensive nephropathy, diabetic nephropathy

Representative Publications

  1. Gerhardstein, B. L., Gao, T., Bunemann, M., Puri, T. S., Adair, A., Ma, H., and Hosey, M. M. (2000).  Proteolytic processing of the C terminus of the a1C subunit of L-type calcium channels and the role of a proline-rich domain in membrane tethering of proteolytic fragments.  J. Biol. Chem., 275, 8556-8563.
  2. Gerhardstein, B. L., Puri, T. S., Chien, A. J., and Hosey, M. M. (1999).  Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit             of L-type voltage-dependent calcium channels.  Biochemistry, 38, 10361-10370.
  3. Gao, T.*, Puri, T. S.*, Gerhardstein, B. L., Chien, A. J., Green, R. D., and Hosey, M. M. (1997). Identification and subcellular localization of the subunits of L-type calcium channel and adenylyl cyclase in cardiac myocytes. J. Biol. Chem. 272, 19401-19407.  *equal contributors
  4. Puri, T. S., Gerhardstein, B. L., Zhao, X.-L., Ladner, M. B., and Hosey, M. M. (1997). Differential effects of subunit interactions on protein kinase A- and protein kinase C-mediated phosphorylation of L-type calcium channels. Biochemistry 36, 9605-9615.

More Information

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