Section of Endocrinology, Diabetes and Metabolism
Associate Professor of Medicine
|BA||1987||The University of Chicago||Biological Sciences
|PhD||1994||The University of Chicago||Pharmaceutical and Physiological Sciences
|Fellowship||1997||Parke-Davis Pharmaceutical Research||Cell Biology
Dr. Brady’s research examines hormonal regulation of glycogen metabolism, including the effects of modulating glycogen levels on insulin metabolic signaling and energy sensing in 3T3-L1 adipocytes as well as an examination of the enzyme responsible for the localized activation of glucocorticoids in vivo and its role in the induction of insulin resistance in adipocytes. His studies will generate new insights into the regulation of insulin sensitivity in adipocytes and potentially the development of insulin resistance and progression to type II diabetes.
- Jurczak, M.J., Danos, A.M., Rehrmann, V.R, Allison, M.B., Greenberg, C.C. and Brady, M.J. (2007) Transgenic overexpression of protein targeting to glycogen markedly increases adipocytic glycogen storage in mice. Amer. J. Physiol. Endocrinol. Metab. 292, E952-E963
- Broussard, J., Ehrmann, D.E., Van Cauter, E., Tasali, E and Brady, M.J. (2012) Impaired insulin signaling in human adipocytes following experimental sleep disturbance. Ann. Int. Med. 157, 549-557
- Zhang, W., Sargis, R.M., Volden, P.A., Carmean, C.M., Sun, X.J. and Brady, M.J. (2012) PCB 126 and other dioxin like PCBs specifically suppress hepatic PEPCK expression by aryl hydrocarbon dependent and independent mechanisms. PLoS One 7, e37103 PMCID:PMC3353882
Carmean, C.M., Bobe, A.M., Yu, J.C., Volden, P.A. and Brady, M.J. (2013) Refeeding-induced brown adipose tissue glycogen hyper-accumulation in mice is mediated by insulin and catecholamines. PLoS One 8, e67807 PMCID:PMC3701606
- Volden, P.A., Wonder, E.L., Ye, H., Kocherginsky, M., Smith, E., Kregel, S., McClintock, M.K., *Brady, M.J. and *Conzen, S.D. Chronic social isolation is associated with metabolic gene expression changes specific to mammary adipose tissue. Cancer Prev. Res. 6,634-645
*Co-corresponding authors. Cover article.