Section of Pulmonary / Critical Care
Associate Professor of Medicine
|MS||1987||Moscow State University||Biology
|PhD||1990||Moscow State University||Biology
Dr. Nickolai Dulin studies the signaling mechanisms of myofibroblast differentiation as related to the pathogenesis of pulmonary fibrosis. This includes the signaling induced by TGF-beta and by G protein coupled receptors, control of cell signaling by actin and microtubule sytoskeleton, activation of mechanosensitive transcription factors and identification of their target genes, and control of these processes through protein phosphorylation. His studies using cultured human lung fibroblasts and animal models of pulmonary fibrosis aim to identify new signaling molecules that could be targeted for potential treatment of this disease.
- Sandbo N, Dulin N. Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function. Transl Res. 2011, 158(4):181-96. Review.
- Sandbo N, Lau A, Kach J, Ngam C, Yau D, Dulin NO. Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-beta. Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L656-66
- Sethakorn N, Yau DM, Dulin NO. Non-canonical functions of RGS proteins. Cell Signal. 2010 Sep;22(9):1274-81. Review. PMID: 20363320.
- Taurin S, Sandbo N, Yau DM, Sethakorn N, Kach J, Dulin NO. Phosphorylation of myocardin by extracellular signal regulated protein kinase. J Biol Chem. 2009, 284(49):33789-94.
- Sandbo N, Kregel S, Taurin S, Bhorade S, Dulin NO. Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. Am. J. Respir. Cell. Mol. Biol. 2009; 41(3):332-8.