Patrick Cunningham
Section of Nephrology
Assistant Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730


BS1990University of Notre DameChemistry
MD1994Tufts University  
Residency1997The University of ChicagoInternal Medicine
Fellowship2001The University of ChicagoNephrology

Academic Interests

Dr. Patrick Cunningham studies the mechanism of Acute Kidney Injury (AKI) using animal models and cell culture experiments, focusing on the importance of the renal endothelium. Specific areas of interest include the roles played by cytokines such as TNF, adhesion molecule expression, apoptosis, and the connection between caspase activation, cytoskeletal changes, and inflammatory signaling in renal endothelial cells. Methods used include tissue immunohistochemistry, confocal microscopy, use of siRNA transfection in cell culture, exploration of mouse renal hemodynamics with implantable flowprobes, and the technique of Blood Oxygen Level Dependence (BOLD)-MRI, as well as the use of mouse kidney transplantation to localize the influence of various mediators. Use of endothelial-specific gene knockout mice using a Cre-lox approach allows insights into the role of crucial mediators, such as TNFR1, within the vasculature during AKI. While especially interested in AKI in the setting of sepsis, Dr. Cunningham’s lab uses various models of renal injury including renal ischemia perfusion to test these hypotheses in other forms of AKI..

Clinical Interests

Acute renal failure and general nephrology.

Representative Publications

  1. Wu X, Guo R, and Cunningham PN. TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho and myosin light chain kinase dependent mechanism. Am. J. Physiol. Renal Physiol., in press, 2009.
  2. Wu X, Guo R, Wang Y, and Cunningham PN. Role of ICAM-1 in endotoxin-induced acute renal failure. Am. J. Physiol. Renal Physiol., 293:F1262-F1271, 2007
  3. Guo R, Wang Y, Minto AW, Quigg RJ, and Cunningham PN. Acute renal failure in endotoxemia is dependent upon caspase activation. J. Am. Soc. Nephrol.15:3093-3102,2004
  4. Cunningham PN, Wang Y, Guo R, He G, and Quigg RJ. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J. Immunol.172:2629-2635,2004
  5. Cunningham PN, Dyanov HM, Park P, Wang J, Newell KA, Quigg RJ. Acute renal failure in endotoxemia is caused by TNF acting on its receptor in kidney. J. Immunol. 168:5817-5823, 2002

More Information

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