Section of Gastroenterology
Professor of Medicine
Vice Chair for Research (Basic)
Referring Physician Access Line: 1-877-DOM-2730
|BA||1986||Universite Paris VII||Biochemistry
|Fellowship||1990||Hôpital Necker, Paris, France||Clinical Immunology & Immunodeficiency
|Residency||1991||Assistance Publique Hôpitaux de Paris||
|Fellowship||1994||National Institutes of Health||Molecular Biology and Allergology
|PhD||1996||Universite Paris VII||Immunology
To face multiple environmental aggressions from pathogens and dietary elements, the intestinal mucosa is colonized by an army of mobile antigen-specific effector T lymphocytes and by a distinct population of resident T cells involved in the tissue stress response. The intestine is in fact the only mammalian site allowing ready access to the effector phase of immune responses in the tissue microenvironment.
Dr. Jabri’s labaoratory overall interest is mucosal and innate immunity, and more specifically the interplay between the immune system and mucosal surfaces. They have a particular interest in intestinal inflammatory diseases, with a focus on celiac disease and inflammatory bowel disease. Her laboratory has expertise in human immunology and is developing mouse models of intestinal inflammation.They use a range of molecular and cellular approaches, including the study of signal transduction, cellular immunology and genetic engineering of mouse models, to study the developmental and functional aspects of immune function in the mouse and human intestine. These studies address basic immunological questions and may lead to novel insights into the mechanisms of inflammatory intestinal diseases and the development of new therapeutic strategies.
- Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. 2011. Science. May 20;332(6032):974-7.
- Yoshida, K., Corper, A.L., Herro, R., Jabri, B., Wilson, I.A., Teyton, L. The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity. J Clin Invest doi:10.1172/JCI41502, 2010.
- Tang, F., Chen, Z., Ciszewski, C., Setty, M., Solus, J., Tretiakova, M., Ebert, E., Han, J., Lin, A., Guandalini, S., Groh, V., Spies, T., Green, P. and Jabri, B.. Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15. J Exp. Med., 2009 Mar 16;206(3):707-19. PMID 19237603
- DePaolo, R.W., Abadie, V., Tang, F., Fehlner-Peach, H., Hall, J.A., Wang, W., Marietta, E.V., Kasarda, D.D. Waldmann, T.A., Murray, J.A., Semrad, C., Kupfer, S. Belkaid, Y., Guandalini, S., Jabri. B.. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature, 471:220-224. 2011.
- DePaolo RW, Tang F, Kim I, Han M, Levin N, Ciletti N, Anderson DM, Schneewind O and Jabri, B. TLR6 drives differentiation of tolerogenic DC and contributes to LcrV-mediated plague pathogenesis. Cell Host & Microbe, 4:350-61, 2008. PMCID 2633104