Marion Hofmann-Bowman
Section of Cardiology
Associate Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730

Training

DegreeYearInstitutionArea
MD1995Ruprecht Karls University, Heidelberg, GermanyMedicine
PhD1995Ruprecht Karls University, Heidelberg, Germany 
Residency1995Heidelberg University Hospital, GermanyMedicine
Fellowship2001Columbia UniversitySurgery
Residency2004North Shore University HospitalMedicine
Fellowship2007The University of Chicago Medical CenterCardiology

Academic Interests

Dr. Hofmann-Bowman is a clinical cardiologist and translational vascular biologist interested in blood vessel diseases of the heart (coronary artery disease) and of the aorta (aortic aneurysms). Her research focuses on blood vessel inflammation mediated by the activation of the receptor for advanced glycation endproducts (RAGE) by pro-inflammatory S100 proteins. She studies the function of S100 proteins in smooth muscle cells and in genetically modified animal models with the goal to find new therapeutic approaches to treat atherosclerosis and to prevent unstable coronary artery disease.


Clinical Interests

General cardiology with a special interest in preventive cardiology, coronary artery disease, aortic valve disease and aortic aneurysms.


Representative Publications

  1. J. Gawdzik, L Mathew, G. Kim, T.S. Puri, MA Hofmann Bowman. Vascular remodeling and Arterial Calcification is directly mediated by S100A12 (EN-RAGE) in chronic kidney disease. American Journal Nephrology, 2011;33:250-259
  2. MA Hofmann Bowman, J Gawdzik, U Bukhari, AN Husain, PT Toth, G Kim, J Earley, EM McNally. S100A12 in vascular smooth muscle accelerates vascular calcification in ApoE null mice by activating an osteogenic gene regulatory program. Arterioscler Thromb Vasc Biol 2011;31;337-344.
  3. MA Hofmann Bowman, J Wilk, A. Heydeman, G Kim, Y Zhang, J Rehman, J. Lodato, J Raman, EM McNally. S100A12 mediates aortic wall remodeling and aortic aneurysm. Circulation Research, 2010 106:145-154.
  4. Ayyasg Melhelm, Ankit Desai, Marion Hofmann. Acute Myocardial infarction and pulmonary embolus in a young man with pernicious anemia-induced severe hyperhomocystenemia. Thrombosis Journal 2009, May 13;7:5
  5. Marion A. Hofmann, Steven Dury, Caifeng Fu, Wu Qu, Akihiko Taguchi, Yan Lu, Cecilia Avila, Neeraja Kambham, Timothy Slattery, Dale Beach, John Mc Clary, Mariko Nagashima, John Morser, Peter Nawroth, Markus F. Neurath, David Stern, and Ann Marie Schmidt. Rage mediates a novel proinflammatory axis: a central cell surface receptor for S 100/ Calgranulin polypeptides. Cell 97: 889-902, 1999



More Information

For more information about Dr. Marion Hofmann-Bowman publications and research collaborations , please click here