Shwu Fan Ma
Section of Pulmonary / Critical Care
Research Associate (Assistant Professor)
|BS||1986||National Cheng Gung Univiserty||Biology
|MS||1988||National Taiwan University||Plant Physiology
|PhD||1996||Indiana University||Physiology and Biophysics
|Fellowship||1997||Indiana University||Molecular Biology
Dr. Ma’s current research focuses on genetic epidemiology of pulmonary diseases including idiopathic pulmonary fibrosis (IPF) and asthma in which the susceptibility and severity varied between individuals and among populations. IPF is a low prevalence, devastating disease characterized by an interstitial fibrotic process and high mortality. The course of IPF is heterogeneous with a 2-5 year median survival from diagnosis. To date, lung transplantation remains the only successful treatment option, while common immunosuppression regimens were recently demonstrated as harmful. The etiology of IPF remains unknown; however, it may integrate multiple genetic loci. Dr. Ma collaborates with Imre Noth, MD and multi-disciplinary team of investigators who are interested in applying recent advances in genetic and assembles an IPF cohort. She and collaborators hypothesize that an independent genome-wide association study (GWAS) in IPF would identify novel genetic variants associated with disease susceptibility and if susceptibility loci associate with mortality. Asthma is a chronic inflammatory disease associated with genetic and environmental factors. She collaborates with Carlos Flores, PhD at Research Unit, Hospital Universitario NS de Candelaria, Tenerife, Spain and explores the genetic variants of asthma associated candidate genes in Asthmatics of Spanish. She aims to identify the predisposed genetic variants within these diseases by case-control association study and their potential therapeutic targets and to develop a platform for genetically-based personalized medicine.
- Zhang X., Zhang W., Ma S. F., Desai A. A., Miasniakova G., Sergueeva A., Ammosova T., Xu M., Nekhai S., Steinberg M. H., Gladwin M. T., Prchal J. T., Kittles R., Garcia J. G. N., Machado R. F., Gordeuk V. R. 2014. The Hypoxic Response Contributes to Altered Gene Expression and Pulmonary Post-Capillary Hypertension in Patients with Sickle Cell Disease. Circulation. Feb 10, 2014.
- Peljto A. L., Zhang Y., Fingerlin T. E., Ma S. F., Garcia J. G., Richards T. J., Silveira L. J., Lindell K. O., Steele M. P., Loyd J. E., Gibson K. F., Seibold M. A., Brown K. K., Talbert J. L., Markin C., Kossen K., Seiwert S. D., Murphy E., Noth I., Schwarz M. I., Kaminski N., and Schwartz D. A. 2013. Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA. 2013 June 5; 309(21):2232-2239.
- Ma S. F., Noth I., Zhang Y., Flores C., Barber M., Huang Y., Broderick S. M., Wade M. S., Hysi P., Scuirba J., Richards T. J., Juan-Guardela B. M., Vij R., Han M. K., Martinez F. J., Kossen K., Seiwert S. D., Christie J. D., Nicolae D., Kaminski N., and Garcia, J. G. 2013. Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. The Lancet Respiratory Medicine. 2013 June; 1(4):309–317.
- Ma S. F., Sun X., Wade M. S., Acosta-Herrera M., Villar J., Pino-Yanes M., Zhou T., Liu B., Belvitch P., Moitra J., Han Y. J., Machado R., Noth I., Natarajan V., Dudek S., Jacobson J., Flores C., and Garcia J. G. 2013. Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 2; 305(7):L467-L477
- Herazo-Maya J. D., Noth I., Duncan S. R., Kim S. H., Ma S. F., Tseng G. C., Feingold E., Juan-Guardela B. M., Richards T. R., Lussier Y., Huang Y., Vij R., Lindell K. O., Xue J., Gibson K. F., Shapiro S. D., Garcia J. G. N., and Kaminski N. 2013. Peripheral Blood Mononuclear Cell Gene Expression Profiles Predict Poor Outcome in Idiopathic Pulmonary Fibrosis. Sci Transl Med. 2013 Oct; 5(205):205ra136